Open AccessModern views on the role of <i>X</i> gene of the hepatitis B virus (<i>Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus</i>) in the pathogenesis of the infection it causes
Author(s) -
Y V Panasiuk,
N V Vlasenko,
N S Churilova,
В. В. Клушкина,
Д. В. Дубоделов,
E N Kudryavtseva,
M I Korabelnikova,
Z S Rodionova,
Т. A. Semenenko,
С. Н. Кузин,
В. Г. Акимкин
Publication year - 2022
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-84
Subject(s) - hepatitis b virus , hepatocellular carcinoma , virology , virus , hepatitis b , population , carcinogenesis , biology , gene , hepatitis c virus , medicine , genetics , environmental health
The review presents information on the role of hepatitis B virus ( Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus ) (HBV) X gene and the protein it encodes (X protein) in the pathogenesis of viral hepatitis B. The evolution of HBV from primordial to the modern version of hepadnaviruses ( Hepadnaviridae ), is outlined as a process that began about 407 million years ago and continues to the present. The results of scientific works of foreign researchers on the variety of the influence of X protein on the infectious process and its role in the mechanisms of carcinogenesis are summarized. The differences in the effect of the X protein on the course of the disease in patients of different ethnic groups with regard to HBV genotypes are described. The significance of determining the genetic variability of X gene as a fundamental characteristic of the virus that has significance for the assessment of risks of hepatocellular carcinoma (HCC) spread among the population of the Russian Federation is discussed.