Open AccessProspects for using low-dose radiation in the complex therapy for COVID-19
Author(s) -
Д. В. Салеева,
Г. Д. Засухина
Publication year - 2021
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-62
Subject(s) - immune system , disease , radiation therapy , covid-19 , regimen , medicine , clinical trial , oxidative stress , low dose radiation , pneumonia , immunology , etiology , bioinformatics , cancer research , oncology , computational biology , pharmacology , biology , infectious disease (medical specialty) , dose–response relationship
This review presents the literature data of new approaches for the treatment of COVID-19 with low doses of radiation (LDR). In addition, data on the use of LDR for the treatment of various disorders, in particular pneumonia, a number of inflammatory processes of various etiology, as well as Alzheimer’s disease are discussed. The mechanisms of LDR action are briefly described, associated with the activation of the immune system and antiinflammatory response due to the effect on the processes of oxidative stress, which is reflected in an increase in the activity of cytokines (interleukin- (IL-) 6), changes in the expression of a number of genes (such as P53 and NF-κB (p65)) and long non-coding RNAs (ncRNAs) (the authors’ own data are presented). Based on the analysis of the material presented, it can be assumed that further clinical trials of the effect of MDR (5–10 cGy) on patients with COVID-19, who are at different stages of the disease, will reveal the optimal conditions for the development and use of an effective treatment regimen.