Open AccessModulation of endothelial factors activity in human endothelial cells in influenza A(H1N1)pdm09 virus infection
Author(s) -
В. А. Марченко,
Svetlana Barashkova,
И. А. Зелинская,
Я. Г. Торопова,
Э. С. Рэмзи,
И. Н. Жилинская
Publication year - 2021
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-48
Subject(s) - enos , virus , biology , plasminogen activator , endothelium , plasminogen activator inhibitor 1 , influenza a virus , endothelial stem cell , virology , immunology , nitric oxide , nitric oxide synthase , endocrinology , biochemistry , in vitro
Influenza A virus infection can lead to endothelial dysfunction (ED), including apoptosis of endothelial cells and modulation of endothelial factor activities. Affected biochemical factors may include those playing important roles in vascular homeostasis. However, the effect of this pathogen on the expression pattern of key endothelial factors is still unknown.The aim of this work was to study the expression of endothelial nitric oxide synthase (eNOS) and plasminogen activator inhibitor-1 (PAI-1, serpin E1) in the EA.hy926 endothelial cells.