Open AccessClinical course and outcomes of chronic viral hepatitis D in patients from Republic of Tuva as endemic region
Author(s) -
Olga V. Isaeva,
Л. Ю. Ильченко,
Anna A. Saryglar,
Anastasia A. Karlsen,
К. К. Кюрегян,
М. И. Михайлов
Publication year - 2021
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-29
Subject(s) - coinfection , medicine , cirrhosis , viral hepatitis , hepatitis , hepatitis d virus , hepatitis b , hepatitis b virus , virus , hepatitis c virus , hepatitis d , disease , virology , liver disease , immunology , hbsag
Hepatitis D (delta, 5) is caused by an RNA virus (hepatitis D virus, HDV) from genus Deltavirus, and is the most severe and difficult to treat disease among both viral hepatitis and infectious diseases in general. The development of HDV infection in the host organism is possible only in the presence of hepatitis B virus (HBV). Coinfection with HBV and HDV is associated with a more rapid progression of chronic viral hepatitis (CVH) to liver cirrhosis (LC) and an unfavorable outcome in comparison with HBV monoinfection. Data on the influence of clinical, biochemical and virological factors on the infectious process in patients with hepatitis D are limited due to the insufficient amount of research on this theme.The study aimed to determine demographic, clinical, biochemical, and virological factors influencing the course and progression of CVH D in patients followed during 10 years, residing in the territory of the Tuva Republic, one of the endemic regions of the Russian Federation.