Open AccessSynthesis and characterization of human rotavirus A (<i>Reoviridae: Sedoreovirinae: Rotavirus: Rotavirus A</i>) virus-like particles
Author(s) -
S. A. Cherepushkin,
В В Цибезов,
Anton G. Yuzhakov,
Oleg Latyshev,
Konstantin P. Alekseev,
E G Altayeva,
К.М. Хаметова,
Г. К. Воркунова,
K A Yuzhakova,
Т В Гребенникова
Publication year - 2021
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-27
Subject(s) - rotavirus , virology , biology , virus , recombinant dna , reoviridae , plasmid , virus like particle , genotype , microbiology and biotechnology , gene , genetics
Rotavirus infection is the leading cause of acute gastroenteritis among infants. The development of new vaccines against rotavirus A is urgent because the virus has many genotypes, some of which have regional prevalence. Virus-like particles (VLP) is a promising way to create effective and safe vaccine preparations.The purpose of the study is to develop the technology for the production of VLP, containing VP2, VP4, VP6 and VP7 of viral genotypes prevalent on the territory of the Russian Federation, and to give its molecular genetic and virological characteristics.