Open AccessAssessment of immunogenic activity of the cloned human rotavirus A WA strain
Author(s) -
Oleg Latyshev,
Olesja Eliseeva,
Л. В. Костина,
Konstantin P. Alekseev,
К.М. Хаметова,
E G Altaeva,
О.A. Verkhovsky,
Т.И. Алипер,
Т В Гребенникова
Publication year - 2019
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-2019-64-4-156-164
Subject(s) - rotavirus , virology , biology , virus , reoviridae , vaccination , immunization , adjuvant , microbiology and biotechnology , diarrhea , antibody , medicine , immunology
Rotovirus infection (RVI) caused by the dsRNA-containing virus from genus Rotavirus, Reoviridae family, belonging to group A (RVA), is the cause of severe diarrhea in human and other mammalian species. Vaccination is the most effective way to reduce the incidence of RVI. At present, the effectiveness of using gnotobiotic piglets as a universal model for reproducing human rotavirus infection and assessing the quality of RVI vaccine preparations has been experimentally proven.