Open AccessModern Conceptions about the Mechanisms of Interaction Between Biofilm and Cellular Immunity Factors
Author(s) -
Н. М. Шлепотина,
М.В. Пешикова,
О. Л. Колесников,
Yu. S. Shishkova
Publication year - 2020
Publication title -
žurnal mikrobiologii, èpidemiologii i immunobiologii
Language(s) - English
Resource type - Journals
eISSN - 2686-7613
pISSN - 0372-9311
DOI - 10.36233/0372-9311-2020-97-1-83-90
Subject(s) - biofilm , immune system , pseudomonas aeruginosa , biology , microbiology and biotechnology , function (biology) , bacteria , microorganism , immunology , genetics
Features of the cellular immune response in the presence of a microbial biofilm are well described in the literature. Based on numerous studies, it became possible to establish a number of patterns: mature biofilms are better protected from immune factors, the effectiveness of antibiofilm strategies depends on species of the microorganisms, forming the biofilm, and, accordingly, on the composition of the biopolymer matrix. For example, rhamnolipids and alginate of Pseudomonas aeruginosa exert a significant negative effect on the function of immunocompetent cells. The bacteria of biofilms became able to turn to their advantage many of the protective reactions developed by the immune system and fixed evolutionarily, applying them for the growth and development of the microbial consortium.