Open AccessANTIMICROBIC MECHANISMS OF NEUTROPHILES AS PERSPECTIVE TARGETS FOR PHARMACOLOGICAL MODULATION OF NON-SPECIFIC PROTECTION OF THE ORGANISM
Author(s) -
Е. В. Матосова,
B. G. Andryukov
Publication year - 2018
Publication title -
žurnal mikrobiologii, èpidemiologii i immunobiologii
Language(s) - English
Resource type - Journals
eISSN - 2686-7613
pISSN - 0372-9311
DOI - 10.36233/0372-9311-2018-3-96-105
Subject(s) - biofilm , antimicrobial , organism , phagocytosis , neutrophil extracellular traps , microbiology and biotechnology , secretion , biology , immune system , bacteria , extracellular , antibiotic resistance , antimicrobial peptides , microorganism , antibiotics , chemistry , immunology , inflammation , biochemistry , paleontology , genetics
Key roles in nonspecific protection of the macroorganism are played by neutrophils — the most numerous pool of leukocytes. During the development of infection these cells phagocytose of microorganisms and also secrete proteolytic enzymes that destroy extracellular pathogens. In addition, they form structures called neutrophil extracellular traps (NETs). But in response, microorganisms have developed a number of mechanisms that allow them to evade neutrophilic attacks, including developing in the form of biofilms in the host organism. In this case, biofilms introduce negative properties into the infectious process: a recurring course, a tendency to chronization, resistance to traditional antimicrobial agents, which can also indicate the inaccessibility of biofilm for cells of the immune system. The purpose of the review: in connection with the development of molecular research and the appearance in science of new methods of visualization, it is necessary to characterize the known antimicrobial mechanisms of neutrophils. In conditions of increasing resistance of bacteria to antibiotic drugs, antimicrobial mechanisms are promising targets for pharmacological modulation of nonspecific defense of the body.