Open AccessEPIDEMIOLOGICAL STUDY OF MAIN CLONES DISTRIBUTION GENOTYPE BEIJING OF MYCOBACTERIUM TUBERCULOSIS WITHIN IRKUTSK REGION
Author(s) -
С. Н. Жданова,
О. Б. Огарков,
V. V. Sinkov,
П. А. Хромова,
Е. А. Орлова,
Mikhail Koscheev,
Е. Д. Савилов
Publication year - 2017
Publication title -
žurnal mikrobiologii, èpidemiologii i immunobiologii
Language(s) - English
Resource type - Journals
eISSN - 2686-7613
pISSN - 0372-9311
DOI - 10.36233/0372-9311-2017-6-88-94
Subject(s) - genotype , beijing , epidemiology , mycobacterium tuberculosis , tuberculosis , typing , molecular epidemiology , dominance (genetics) , biology , transmission (telecommunications) , population , genotyping , locus (genetics) , virology , demography , veterinary medicine , geography , genetics , medicine , environmental health , china , gene , pathology , electrical engineering , archaeology , engineering , sociology
Aim. To estimate the dynamics changes in the population structure of the tuberculosis (ТВ) pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuberculosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were born before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of CC1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.