Open AccessMOLECULAR AND GENETIC FEATURES OF THE METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) - CAUSATIVE AGENTS OF PURULENT DISEASES AT CANCER PATIENTS
Author(s) -
Olga E. Khokhlova,
О. В. Перьянова,
О. П. Боброва,
В. К. Сергеева,
А. А. Модестов,
О. Г. Еремеева,
Н. К. Поткина,
Д. Н. Капшук,
А. В. Алабушева,
Tatsuo Yamamoto
Publication year - 2017
Publication title -
žurnal mikrobiologii, èpidemiologii i immunobiologii
Language(s) - English
Resource type - Journals
eISSN - 2686-7613
pISSN - 0372-9311
DOI - 10.36233/0372-9311-2017-6-15-20
Subject(s) - staphylococcus aureus , antibiotics , microbiology and biotechnology , cancer , biology , antibiotic resistance , methicillin resistant staphylococcus aureus , medicine , genetics , bacteria
Aim. Study of the molecular and genetic features of the MRSA, causative agents of purulent diseases at cancer patients. Materials and methods. In the work were used - bacteriological method, molecular genetic methods (PCR, M-PCR, sequencing). Results. MRSA share among staphylococcal infections at cancer patients in 2003 - 2007 has made 37,6%, and in 2010 - 2015 has increased up to 51,3%. At a research of molecular and genetic features of the allocated MRS A ] strains, have established, existence of two main clones: ST239/spa3(t037)/SCCmecIIIA and ST8/ . spal(t008)/SCCmecIVc. Representatives of clones differed in resistance level to antibiotics. Conclusion. In cancer patients in Krasnoyarsk, the distribution of two variants of MRSA-ST239Kra$ and ST8Kras, corresponding to the variants common in the Krasnoyarsk region, was revealed. i