Open AccessCOMPARISON OF EFFICACY OF TAMOXIFEN CITRATE AND CLOMIFENE CITRATE IN OVULATION INDUCTION- PRIMARY INFERTILITY
Author(s) -
sonal Tahaliyani,
Alla Sathyanarayana Reddy,
Narmadha Narmadha
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/9412026
Subject(s) - clomifene , ovulation induction , ovulation , tamoxifen , infertility , medicine , gynecology , unexplained infertility , andrology , pregnancy , biology , hormone , cancer , breast cancer , genetics
BACKGROUND – Ovulation Induction refers to the therapeutic restoration of the release of eggs per cycle inwomen.The aim of the study is to compare the effectiveness of Tamoxifen citrate and Clomifene citrate in ovulationinduction and to compare the age wise efficacy of the drug. METHODS:A total of 90 infertility patients were included inthe study, and 45 were allocated to group A and 45 in group B.Group A was given Clomifene citrate 50 mg and group Bwas given Tamoxifine 40 mg from day 5 to 9.RESULTS: The number of patients who ovulated in first cycle is 26.6%,second cycle 40% and third cycle is 26.6% in group A. In group B the number of patients who ovulated in first cycle is24.4%. second cycle 48.8%, third cycle 20% respectively.The mean pregnancy rate in clomifene group is 22.22% anstamoxifen is 24.4% with P value of >0.05 showed no significant difference in both group.CONCLUSION:Tamoxifen wasbetter drug for ovulation induction when compared with clomifene citrate which is standard drug usually used forovulation induction. This is because of the endometrial thickness which is needed for implantation is better withtamoxifen..