THYROID SWELLING AND IT’S ASSOCIATION WITH THYROID HORMONE STATUS AND BLOOD LIPID PROFILE: A CROSS-SECTIONAL STUDY

Disease of thyroid gland are among the most abundant endocrine disorder in the world second only to diabetes mellitus .Thyroid diseases namely hypothyroidism and hyperthyroidism,constitutes the most common endocrine abnormality inrecent years,diagnosed either in subclinical or clinical form.One observational cross sectional study was conducted inthe department of ENT, Tripura Medical College & DR.BRAM Teaching hospital involving 75 nos of subjects havingthyroid swellings. Mean value of T3,T4 and TSH was different in cases of euthyroid, hypothyroid , hyperthyroid andsubclinical hypothyroid subject. It was of statistically significant. Here P value of T3, T4 & TSH according to thyroidhormone status were less than 0.05(α%) level of significance.There was statistically difference in average value of T3,T4& TSH with different thyroid hormone status at 5% level of significance.We found that 9.3% of the study subjects werehaving altered lipid profile.We found that 62.5% of hypothyroid subjects were having altered lipid profile . Amongstthem,all subclinical hypothyroid subjects were having altered lipid profile.Whereas hyperthyroid subjects were havingnormal lipid profile.Two (3.07%) euthyroid cases were having altered lipid profile.We found that mean values of totalcholesterol, triglyceride, HDL, LDL and VLDL was different in cases of euthyroid , hypothyroid , hyperthyroid andsubclinical hypothyroid subject.It was of statistically significant.Here P value of total cholesterol,triglyceride,HDL,LDLand VLDL according to thyroid hormone status were less than 0.05(α%) level of significance. There was statisticallydifference in average value of total cholesterol,triglyceride,HDL,LDL and VLDL with thyroid hormone status at 5% levelof significance.