Open AccessANALGESIC EFFECT OF BRYOPHYLLUM PINNATUM L AND CURCUMA XANTHORRIZA COMBINATION ON MICE'S INDUCED BY FORMALDEHYDE AS ARTHRALGIA AGENT
Author(s) -
Tuti Sri Suhesti,
Hanif Nasiatul,
Mustofa Mustofa
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/8607775
Subject(s) - analgesic , rhizome , traditional medicine , curcuma , formaldehyde , pharmacology , medicine , aspirin , nociception , chemistry , biochemistry , receptor
Arthralgia is pain in arthritis. Its prevalence is widespread and increasing every year and greatly affect quality of life.Bryophyllum pinnatum L (BP) leaves and Curcuma xanthorriza (CX) rhizomes potensially as antioxidant, analgesic andanti-inflammatory.In this study we examined the analgetic effects of both ethanolic BP and CX extract's combination onthe analgetic score using formaldehyde induced.Male mice strain balb/c were divided into 7 groups (n=7), consists ofcontrol group (aquadest),aspirin group at a dose of 100mg/ mL,ethanolic extract group with various doses at 200mg/kgBB, p.o. Each group was induced by 0.05 ml Formaldehyde (2.5%) on day. Early phase nociceptive responses weremeasured in the first 5 minutes and late phase was measured at 15-30 minutes after formaldehyde induced.The analgeticscore were determined on early phase and late phase,and then analyzed using ANOVA test.The results showed that thecombination of BP and CX extract have analgesic activity in male mice's were induced by formaldehyde. Dosecombination of BP and CX with a dose of 100:0 significantly showed optimum analgetic score.The results suggest that BPextract had analgetic activities that should be further examined and potentially candidate as exploited for arthralgiatherapies