Open AccessPREVALENCE OF HELICOBACTER PYLORI IN PATIENTS OF GASTRIC CARCINOMA
Author(s) -
Sandeep Chandrakar,
Rajendra Ratre,
Neeraj Kumar,
T Narasimha Murty
Publication year - 2022
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/8501801
Subject(s) - helicobacter pylori , medicine , gastroenterology , cancer , carcinoma , biopsy , population , stomach , pathology , environmental health
: H. pylori is a gastric pathogen that colonizes approximately 50%-60% of the world's population.Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastriculcer disease and gastric carcinoma. This study is undertaken to determine the clinical and pathological profile ofgastric carcinoma in our institute and to find out the prevalence of H. pylori infection in gastric carcinoma patients.MATERIALS AND METHODS :We conducted our study in the Department of Surgery, Dr. B. R. A. M. Hospital, Raipur,C.G. over a period of 18 months. It was a hospital based, cross-sectional observational study. During upper GI endoscopy,site of the lesion and macroscopic type of the lesions were identified and recorded. Multiple tissue biopsy samples (>10)were collected from non-necrosed region of cancer. One piece of each paired specimen were immediately subjected toRapidUrease Test dry kit (RUT) for detection of Helicobacter pylori. Further these biopsy specimens were subjected tomodified giemsa staining and culture.RESULTS : Out of the 70 cases of gastric carcinoma, the prevalence of H.pylori was 64.28% . The most common age groupassociated with gastric carcinoma with H.pylori infection was more than 60 years. There was male predominance seenfor both gastric carcinoma and gastric carcinoma positive for H.pylori infection. The most common lesion for gastriccarcinoma and those positive for H.pylori was ulceroproliferative type. The most common site of stomach involved incases of Gastric carcinoma associated with H.pylori infection was antrum+pylorus of stomach. The most commonhistological type of gastric carcinoma associated with H.pylori infection was poorly differentiated adenocarcinomaCONCLUSION : On the basis of our study it is evident that H.pylori is an independent risk factor for gastric carcinoma..Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastriculcer disease and gastric carcinoma.