GESTATIONAL TROPHOBLASTIC DISEASE - DEMOGRAPHIC, CLINICAL AND HISTOPATHOLOGICAL PROFILE AT A TERTIARY CARE HOSPITAL IN KASHMIR.

BACKGROUND: Gestational trophoblastic disease encompasses a spectrum of tumors and tumor-like conditionscharacterized by abnormal proliferation of pregnancy associated trophoblastic tissues of varying abilities for invasionand spread . GTD lesions are histologically distinct and can be benign or malignant. Gestational trophoblasticneoplasms are now some of the most curable of all solid tumors, with cure rates of 90% even in the presence ofwidespread metastatic disease.MATERIALS AND METHODS: It was a retrospective observational study carried out at the department of obstetricsand gynecology gmc srinagar. The demographic and clinical data as well as histopathology of all the consecutivepatients with molar pregnancy admitted between January, 2019 and December, 2019 were retrieved and entered intoprepared proformas.RESULTS: Our study population included a total of 58 patients.The incidence in our study was 5.01/1000deliveries.Majority of patients in our study were in the age group of 20-30 years i.e.48.3%. 58.6% patients in our studypopulation were illeterate while as most patients belonged to lower middle class i.e. 44.8%. 24.1% patients in our studywere primigravida while as 55.2% had a previous term pregnancy.Maximum patients presented in first trimester i.e.51.7%. All patients in the study presented with a period of ammenorrhea followed by bleeding PV(72.4%),hyperemesis(44.8%) and passage of grape like vesicles(25.9%). 3 patients had acute heamorrhagic shock onpresentaion. Maximum patients (84.4%) had USG documented molar pregnancy.Majority of patients(88%) belonged tolow risk as per FIGO staging. 37.9%patients had blood group A while 32.8% had blood group B. On histopathology 50%patients had partial mole followed by complete mole in 38%. Invasive mole was seen in 10.3% while choriocarcinomaaccounted for 1.3%.This study reported no case of PSTT.CONCLUSION:GTNs are among the rare human tumours that can be cured even in the presence of widespreaddissemination. Thus an early and accurate differential diagnosis is important for patient councelling and perinatalmanagement but also for preservation of fertility.