Open AccessPROCALCITONIN AS A DIAGNOSTIC MARKER FOR SEPSIS AND ANTIBIOTIC THERAPY IN SURGICAL CARE PATIENTS
Author(s) -
Ved Prakash,
Priya Umapathi,
Mahesan Ganesan
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/6704746
Subject(s) - procalcitonin , medicine , sepsis , biomarker , septic shock , intensive care medicine , c reactive protein , prospective cohort study , inflammation , biochemistry , chemistry
Background: Sepsis is becoming a frequent complication in hospitalized patients. Early and differential diagnosis ofsepsis is needed critically.Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortalityis unclear. Aim: To study about the utility of procalcitonin as a diagnostic biomarker for bacterial infections and itsefficient use as a marker for antibiotic therapy. Materials and methods:This prospective observational study wasconducted among patients admitted with Septicemia in a tertiary care hospital from January 2019 to May 2020.In Sixtyconsecutive patients of sepsis,Procalcitonin (PCT),C-reactive protein (CRP) measurements were recorded in addition totheir demographic, laboratory values and treatment outcomes. Results:Mortality rates were 6.5%, 28.6% and 62.5%respectively in the three groups of sepsis, severe sepsis, and septic shock, respectively. It was inferred that more theseverity of sepsis,more is the positivity rate of serum procalcitonin levels. Similarly,the serum PCT values were higheramong non-survivors [13.1ng/dl]. Procalcitonin value was a better predictor of all-cause short-term mortality than Creactive protein as denoted by ROC analysis. Conclusions: PCT done once at the time of admission was proven to bevery good,cost effective biomarker for the early identification of sepsis better than CRP levels and cultures.