Open AccessA PROSPECTIVE OBSERVATIONAL STUDY TO ASSESS ROLE OF ISOLATED HYPERBILIRUBINEMIA TO PREDICT GANGRENOUS/PERFORATED APPENDICITIS
Author(s) -
Sudhanshu Choudhary,
Dinesh Bharti,
Anupama Nagar,
Shalu Gupta,
Saurav Kumar
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/5001537
Subject(s) - medicine , appendicitis , appendix , perforation , acute appendicitis , alvarado score , gastroenterology , prospective cohort study , observational study , surgery , paleontology , materials science , metallurgy , punching , biology
Aim:Theaimof studywas toassess theroleofhyperbilirubinemiaasapredictorofgangrenousorperforated appendicitis.Introduction: Appendicitis is characterised by means of infection and inflammation of the appendix. It washypothesized that an association exists between the presence of appendiceal perforation and hyperbilirubinemia.Thepresent study has been designed to evaluate the association between hyperbilirubinemia in cases of acute appendicitisand its complications.Methods: This study was conducted at SMS hospital Jaipur as a prospective observational study. One hundred twentypatients of appendicitis were enrolled from 1 March 2017 to 30 November 2018 according sample size. Patientsunderwent appendectomy after confirmation of diagnosis by USG and other investigations and biopsy was sent forhistopathological examination.Results: Total 120 patients were analysed In our study as per inclusion criteria. Hyperbilirubinemia (>1.2 mg/dL) wasfound in gangrenous appendicitis and perforated appendicitis (91.67% and 100% respectively) as compared to inacute appendicitis (15.63%) cases (P<0.001). most of the acute (84.37%) and some gangrenous appendicitis (8.33%)patients had normal TSB but all perforated appendicitis patients had hyperbilirubinemia (>1.2 mg/dL). Liver enzymeswere normal in most of cases or slightly elevated in some cases.Alvarado Score and CRP were also significantly elevatedin complicated appendicitis than acute appendicitis.Conclusion: Our study concluded that isolated hyperbilirubinemia is a predictor of perforated or gangrenousappendicitis.High Alvarado Score and CRP level are also indicating complicated appendicitis.