MUTATIONS IN PULMONARY ADENOCARCINOMA. FREQUENCY STUDY FROM A ONCOLOGY CENTRE IN CENTRAL KERALA.

Background: Non small cell carcinomas of lung, notably adenocarcinoma is associated with genetic mutations in EGFR(chromosome 7) , ALK (chromosome 2), ROS1(chromosome 6) . The patients harbouring these mutations are greatlybenefited from tyrosine kinase inhibitor targeted chemotherapy. The prevalence of these mutations in central kerala hasnot been studied and documented.Aim: This study aims to analyse the frequency of different mutations in lung adenocarcinomas presenting to a oncologycentre in kerala.Study Design: Descriptive study.Materials And Methods: The study spanned over a period of two years from 2019-2021. A total of 169 consecutive lungadenocarcinomas were studied.PCR for EGFR was done in 89 cases and were tested for the common mutations. ALK1 IHC using ALK-D5F3 clone and ROSwith ROS-D4D6 clones were done in 40 cases.Results: EGFR mutation was present in 15 cases (17.44%). The most common age range was 40-60yrs. Two mostcommon patterns were solid and acinar. ALK and ROS 1 mutation was found in 3 cases (7.5%) and 2 cases ( 5%)respectively. 4 cases (16.66%) of EGFR mutant lung adenocarcinoma patients had metastasis.