Open Access“PREVALENCE OF BETA-THALASSEMIA TRAIT IN PREGNANT WOMEN ATTENDING ANTENATAL CLINIC”
Author(s) -
Uma Jain,
Preeti Gupta,
Shaily Sengar
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/4706167
Subject(s) - medicine , thalassemia , anemia , pediatrics , asymptomatic , pregnancy , gestational age , family history , incidence (geometry) , beta thalassemia , iron deficiency anemia , obstetrics , microcytic anemia , genetics , physics , optics , biology
- Iron deficiency anemia and thalassemia syndromes,especially beta thalassemia trait (BTT),are thetwo most commonly ccuring microcytic hypochromic anemias highly prevalent in countries like India. Iron deficiencyanemia is the first most common cause of anemia in pregnancy,beta thalassemia trait is the second most frequent causeof anemia of pregnancy.Patients with thalassemia trait shows an increased incidence of anemia during the second trimester of pregnancy.Beta Thalassemia Trait (BTT) patients are usually asymptomatic and ignorant of their carrier state unless diagnosed bytesting.Screening for thalassemia can be done by measuring HbA2 levelsMATERIAL AND METHOD- This is a retrospective study. The data were collected from a clinic and associatedst pathology in Shivpuri and a private maternity hospital in Gwalior from 1 January 2019 to 30 June 2021.94 patients wereincluded in the study.All pregnant women between the age of 18-45 years and at any gestational age with hemoglobinlevel <10g/dL and microcytic hypochromic anemia (report of CBC) were included in the study. High-PerformanceLiquid Chromatography (HPLC) and serum ferritin report were collected.RESULTS- In our study the most common age group in which the anemia was found between 19-35 years (80.85%).Mostof the patients were primigravida (44.68%),between 26-37 wks of gestational age (82.97%),from a rural area (70.21%).Only 2 patients had a family history (2.12%) of beta-thalassemia and 6 patients had a history (6.38%) of bloodtransfusion.In our study moderate anemia was found in 55.31% of cases followed by mild anemia 25.53% and severe anemia 19.14%.In our study iron deficiency anemia was found in 87.23% only minor Beta-thalassemia was found to be 4.25%, of thepatient,and the coexistence of iron deficiency anemia and beta-thalassemia in pregnant women is 8.51%.In our study total of 12 patients (4 cases of only minor beta-thalassemia and 8 cases of minor beta-thalassemiaassociated with IDA) The prevalence rate of beta-thalassemia in our study was 7.8%.CONCLUSION- the recommendation is to diagnose beta-thalassemia in pregnant patients is essential to give propertreatment.The screening of pregnant patients prevents unnecessary parental iron therapy and iron overload in case ofanemia.further studies are needed in this field and less expensive and accurate methods should come in place.