LOW DOSE HCG IN PREVENTING OHSS IN HIGH-RISK WOMEN

Ovarian hyperstimulation syndrome(OHSS) is a complicationof fertility treatment, which uses pharmacological ovarianstimulation to increase the number of oocytes and thereforeembryos available during assisted reproductive technology(ART).Severe ovarian hyperstimulation syndrome (OHSS) iswell known to be a rare but potentially fatal condition inanovulatory women with polycystic ovarian syndrome(PCOS) when undergoing IVF. Low-dose stimulation is thusrecommended,but it can still lead to ovarian hyperstimulationassociated with high serum oestradiol concentrations by thetime leading follicles reach maturity. Several methods have,therefore, been applied to prevent OHSS. First, riskassessment is made on the basis of the previous history ofOHSS and the identification of women with PCO. Second, intreatment cycles a high concentration of oestradiol and threeultrasound parameters (i.e. high number of follicles, largeovarian volume, and high stromal vascularity) on the day ofhuman chorionic gonadotrophin (HCG) are all predictive ofincreased risk of developing OHSS.