Open Access“ENHANCING TELMESARTAN BY USING SOLID DISPERSION TECHNIQUES”
Author(s) -
Praveen Kumar Shakya,
Sushil Kumar,
Mansi Singh,
Savita Savita
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/4310548
Subject(s) - telmisartan , solubility , biopharmaceutical , bioavailability , solvent , dispersion (optics) , chemistry , combinatorial chemistry , aqueous solution , absorption (acoustics) , materials science , chemical engineering , pharmacology , organic chemistry , medicine , genetics , physics , composite material , biology , blood pressure , optics , radiology , engineering
Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. Telmesartan (TLM) is anorally active direct-acting Angiotensin1receptor antagonist and possess therapeutic potential in the pharmacotherapy ofhypertension. Telmisartan is classified as a class II medicine by the BCS (biopharmaceutical categorization system), and it isnearly insoluble in water, with a low solubility profile and poor absorption. Drugs with poor aqueous solubility are still anongoing challenge in the successful formulation of therapeutic products due to their low oral bioavailability. Soliddispersions are a dispersion mixture of one or more active ingredients in an inert carrier at the solid state prepared bymelting, solvent, solvent-melting or other methods. Cyclodextrins(CDs) with their cylinder-shaped cavities are capable toform inclusion complexes with a wide range of commonly used drugs. Complexation of molecules to CDs occurs through anon-covalent interaction between the molecule and the CD cavity. This is a dynamic process whereby the guest moleculecontinuously associates and dissociates from the host CD. The present study is to improve the solubility of Telmisartan bysolid dispersion techniques using various methods and proved to be effective for further pharmaceutical usage.