STUDY ON OUTCOME OF SINGLE MORNING TOTAL DOSE OF ORAL PREDNISOLONE VERSUS DIVIDED DOSE OF ORAL PREDNISOLONE IN TREATMENT OF STEROID SENSITIVE NEPHROTIC SYNDROME

Nephrotic syndrome is a common renal disorder characterised by Massive proteinuria (>40 mg/m2/day); hypoalbuminemia and edema. Relapses of nephrotic syndrome are usually treated with prednisolone. Study was aimed to compare the efficacy, complication and compliance of single morning daily total dose versus divide daily dose of oral prednisolone in treating steroid sensitive nephrotic syndrome(SSNS). The study was conducted on patients diagnosed as 1st attack Nephrotic Syndrome or relapse case with SSNS visiting nephrology clinic and admitted in pediatric ward in S.S.G Hospital Vadodara. Total 60 patients were taken in prospective randomised observational study.Patients with 1st attack or relapse were randomized to receive prednisolone 2 mg/ kg per day, either as a single dose (Group A) or in divided doses (Group B) until remission, followed by 1.5 mg/kg on every alternate day. Complication parameters Blood Pressure, Random Blood Sugar, urine output and GI upset were noted. Data was analysed by applying standard statistical test and Med CalC. We observed that average time take for remission after starting the treatment in group A and group B was 14.13 and 17.13 days. Compliance was observed better with single dose then divided dose and fluctuation in blood pressure, random blood sugar, GI upset were observed more with divided dose. Study concluded that single dose did not suppress HPA axis.