FORMULATION AND EVALUATION OF NANOPARTICLES WITH NEURO PROTECTIVE CHEMICALS OF NATURAL AND SYNTHETIC ORIGIN.

Most of the active phytoconstituents under development are poorly water soluble or have poor bioavailability .Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems and limitations ofphytochemicals. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The mainadvantage is that they are prepared with physiologically well-tolerated lipids.Solid Lipid Nanoparticles (SLNs) as novellipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems ofpolymeric nanoparticles.In present research formulation and evaluation of nanoparticles with ethanolic extract of twoplants Celastrus paniculatus and Bacopa monnieri along with Donepezil as a standard drug was undertaken here for theproduction methods for preparation of SLNs, and pharmaceutical approach of SLNs in drug delivery . The focus ofnanoparticle design over the years has evolved toward more complex nanoscopic core–shell architecture using a singledelivery system to combine multiple functionalities within nanoparticles which combine the mechanical advantages ofbiodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust andpromising delivery platform.Solid liquid nanoparticles having plant extracts were successfully formulated and characterized for their stability.Abiodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. This architecture canprovide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multipletherapeutic agents, drug release profile,and good serum stability of phytochemicals