Open AccessEFFECT OF MAGNESIUM SULFATE AND CLONIDINE IN ATTENUATING HEMODYNAMIC RESPONSE IN LAPAROSCOPIC CHOLECYSTECTOMY -A CLINICAL COMPARATIVE STUDY
Author(s) -
Suneeta Dutta,
Zahid Ahmed,
Deba Gopal Pathak
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/4207267
Subject(s) - medicine , pneumoperitoneum , clonidine , anesthesia , blood pressure , intubation , laryngoscopy , hemodynamics , heart rate , mean arterial pressure , surgery , laparoscopy
- Laryngoscopy and tracheal intubation invariably causes hypertension and tachycardia andsubsequent pneumoperitoneum and changes in patient position required during laparoscopic surgeries add to theinsult. In patients with cardiovascular co-morbididities, such alterations can cause severe life threatening situations1perioperatively .Various drugs have been tried to attenuate these effects and in this regard,clonidine,and magnesiumsulfate have shown promising results.AIM- This study was aimed at comparing the efficacy of clonidine and magnesium sulphate in attenuating thehemodynamic responses to laryngoscopy, intubation and pneumoperitoneum, assessed in terms of heart rate, systolicblood pressure,diastolic blood pressure and mean arterial pressure.INCLUSION CRITERIA:Patients between age 18-60 years, of both sexes, ASA grade I&II and scheduled for electivelaparoscopic cholecystectomy under general anesthesia.EXCLUSION CRITERIA:Refusal to informed consent,anticipated difficult airway,ASA grade III&IV,history of allergy tostudy drug, pregnant and lactating mother, any disorders of cardiovascular system, respiratory system, renal system,hepatic and neuromuscular condition.METHODS-:A randomized prospective study was conducted in Silchar Medical College and Hospital, Silchar, and 80patients were randomly allocated to two groups of 40 patients each.One group received clonidine 1.5mcg/kg whereasother group received MgSO4 50mg/kg.HR,SBP,DBP,and MAP were recorded at baseline,after infusion of the study drug,just before intubation, after intubation at 1min,3mins,and5mins, after pneumoperitoneum at 5min,10min,20min,and30min.All analyses were done by using two tailed test p-value.RESULTS: The mean values in HR,SBP, and MAP values at at various intervals were statistically significant (p<0.05) inclonidine group when compared to MGSO4 group.CONCLUSION: Clonidine was found more effective than MGSO4 during laryngoscopy and intubation while both wereequally effective during pneumoperitoneum which correlated with other similar studies.