Open AccessPATTERN OF CLINICAL PRESENTATION OF HYPERPLOLACTINEMIA AMONG INFERTILE PATIENTS
Author(s) -
Uma Jain,
Deepali Jain,
Ashi Jain
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/3607292
Subject(s) - galactorrhea , medicine , anovulation , infertility , amenorrhea , prolactin , bromocriptine , gynecology , ovulation , menstrual cycle , etiology , obstetrics , hormone , pregnancy , obesity , polycystic ovary , insulin resistance , biology , genetics
– The prevalence of hyperprolactinemia ranges from 0.4% in unselected normal adult females to ashigh as 9%–17% in females with reproductive health disorders.The etiology of hyperprolactinemia maybe pathological,physiological or pharmacological Drugs that stimulate the hypothalamic dopamine system and/or pituitary ordopamine receptors can cause elevated prolactin.Clinical features of hyperprolactinemia include menstrualdisturbances (Oligo-amenorrhea, amenorrhea and irregular menses), anovulation, infertility galactorrhea or acombination of the above symptoms.MATERIAL AND METHOD- This is a retrospective of 88 Infertile females with documented Hyperprolectinimea.Theclinical data and infertility workup (Hormonal profile, Imaging report and other tests)were obtained fromgynaecological OPD.RESULTS- In this study the maximum number 54 (61.36%) of patientswere in the 21-25 years of age group,65 (73.86%)of patients were of normal weight and 20 (22.72%) of patients were overweight only 3 (3.40%) were obeseIn this study,the maximum number 60(68.18%)of patients were in primary infertility and 85 (96.59%) of patients had inmild rise in the prolactin level group.In this study, most of the patients 27 (30.68%) of patients were presented with complaints of oligomenorrheaandfollowed by Amenorrhea 21 (23.86%).Galactorrhea was found in 25(28.40%) patients after clinical examinations,bothamenorrhea and galactorrhea were seen in20(22.72%)of the patients. Hypothyroidism was present in 13 (14.77%) ofpatients.CONCLUSION– Anovulatory cycle, Luteal face defect and sex hormonal imbalance caused by hyperprolactinemiaresults in infertility.Prolactin may stop ovulation and cause amenorrhea, in less severe cases Intermittent ovulation orovulation that takes a long time to occur causes infrequent or irregular periods.that's why estimation of serum prolactinshould be done at an early stage of an infertility workup. In our study, the prevalence of hyperprolactinemia andhypothyroidism was found very high which emphasize the importance of estimating TSH and Prolactin in infertility.In ourstudy Oligomonorrhea,amenorrhea and galactorrhea are the commonest presentations in hyperprolactinemia.ProperDiagnosis and treatment results in an improvement in symptoms and an increase in conception rates in infertile patients.