Open AccessCHANGES IN BLOOD DURING STORAGE FOR TRANSFUSION
Author(s) -
Athanasios V. Bakaloudis,
Marianna G. Andreadou,
Irini M. Kalogiannidou,
Nazli O. Osman,
Konstantinos S. Mavromatidis
Publication year - 2022
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/2909235
Subject(s) - hematocrit , medicine , pco2 , bicarbonate , potassium , sodium bicarbonate , blood transfusion , acidosis , sodium , blood pressure , hemolysis , surgery , physiology , anesthesia , chemistry , organic chemistry
Over the past 20 years, extensive research has been conducted on blood transfusion and the hazardsarising from them, as well as on safest maximum storage duration for blood derivatives. Blood transfusion rates inpatients with and-stage renal disease may have declined markedly after the discovery and use of erythropoietin in themid-1980s, but is still remains a standard of care. Since several biochemical changes take place in stored blood,physicians should be alert when transfusing blood in end-stage renal disease patients,who are,theoretically at least,athigher risk of complications.Methods and Results: This study were designed to investigate changes in storer blood over time (every 10 days from 0to 40 days). Changes in sodium, potassium, chloride, total calcium, lactate, pH, partial pressure of carbon dioxide,bicarbonate and hematocrit,as well as the degree of hemolysis,were recorded.The findings show a significant increasein potassium,lactate,partial pressure of carbon dioxide and hematocrit and a reduction in chloride,pH and bicarbonate.The serum levels of sodium initially increased (up to day 20) and then declined.Conclusions: In conclusion, stored blood undergoes significant changes, which can be life-threatening, especially+ when the transfusions are massive or in patients with end-stage renal disease,who are more sensitive to significant K oracid overload.