Open AccessA STUDY OF CORRELATION OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24HOUR URINARY PROTEIN IN TYPE 2 DIABETES MELLITUS PATIENTS AT A TERTIARY CARE HOSPITAL
Author(s) -
Kamlesh J. Upadhyay,
Chaital S. Patel,
Nupur Shah,
Zenith M. Damor,
Arjun C. Jadav,
Manjula K. Damor,
Vippashyna Manyavar
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/2600920
Subject(s) - creatinine , medicine , proteinuria , urine , renal function , diabetic nephropathy , urology , urinary system , diabetes mellitus , excretion , endocrinology , kidney
Background:Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independentrisk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of primeimportance in the diagnosis and management.Method: The present study is a prospective observational study conducted amongst 50 diabetic subjects in Medicinedepartment & IKDRC,Civil Hospital Ahmedabad.The study carried out during the period between July 2017 to October2019. All patients were treated as per standard treatment protocol. 24-hour urine protein and random urine protein tocreatinine ratio (P:C) was determined.Result: Total 50(24 male &26 female) patients were studied. A strong correlation was found between 24 hours urineprotein and protein- Creatinine ratio, especially in patient with eGFR >30 (CKD stage I to III) with coefficient ofcorrelation of 0.973.However correlation weaken as the GFR worsens and is weakest in patients with stage 5 CKDConclusion: The random urine Protein:Creatinine ratio predicts the amount of 24-hour urinary protein excretion withhigh accuracy.Hence it can be used as a faster substitute test for 24-hour urinary protein estimation.