STUDY THE FIBROSIS AND HYPERTROPHY OF LIGAMENTUM FLAVUM IN LUMBAR SPINAL CANAL STENOSIS DUE TO LEPTIN INDUCED INFLAMMATIO

Lumbar spinal stenosis (LSS) is defined as the narrowing of the spinal canal with cord or nerve root impingement and asconsequences the symptoms of radiculopathy or pseudoclaudication are developed. Hypertrophy of the ligamentumflavum (LF) is often involved in the pathogenesis of LSS, resulting in the reduction of diameter of the spinal canal andcompression of the dural sac and nerve roots.Leptin's important role in various biological functions further than appetiteregulation and energy metabolism.Interestingly collective evidence suggests it has a critical role in the fibrosis processin multiple organ systems, including the liver, kidney, and lung. The aim of this study was to establish a relationshipbetween serum leptin levels and the fibrosis and hypertrophy of ligamentum flavum in lumbar spinal canal stenosis.METHOD: Our study include 100 patient with ligamentum flavum hypertrophy with lumbar canal stenosis to evaluateco-relation with increased serum leptin levels. Demographic data, clinical, radiological and laboratory investigationdone to find a co-relation between increased serum leptins levels with the fibrosis and hypertrophy of ligamentumflavum in lumbar canal stenosis.RESULT:In our study,LF thickness was also measured with a T1weighted axial MRI.Themean thickness in the high vas scores (> 5) group was signicantly thicker than that in the low vas (< 5) group. Serumleptin values were positively correlated to LF Thickness at L4-L5 (r=0.228) and L5-S1 (r=0.198) level and the correlationwas significant (p>0.05). CONCLUSION: Our study has shown strong correlation between serum levels of leptin andhypertrophy of ligamentum flavum.VAS score in low VAS group ( 5) are positivelycorrelated with serum levels of leptin