Open AccessA STUDY DESCRIBING THE USAGE PATTERN OF ANTIMICROBIALS WITH INSIGHTS INTO ANTIMICROBIAL DRUG-DRUG INTERACTIONS AMONG ADULT POPULATION IN HOSPITAL SETTINGS
Author(s) -
Tabassum Fathima,
R Prukruthi,
Athira Manikandan,
Muhammed Ramees P K,
Leena Pavitha P
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/2006770
Subject(s) - antimicrobial , medicine , cefuroxime , piperacillin , drug , antimicrobial drug , tazobactam , drug interaction , ciprofloxacin , antibiotics , population , metronidazole , intensive care medicine , pharmacology , imipenem , antibiotic resistance , microbiology and biotechnology , biology , genetics , environmental health , bacteria , pseudomonas aeruginosa
The study aims to describe the use of antimicrobials among adult population in hospital settings with emphasis on theantimicrobial therapy provided and potential antimicrobial drug-drug interactions identified. 108 adult patients whowere prescribed antimicrobials were considered for this retrospective study which was carried out over a period of 3months. It was identified that antimicrobials prescribed were largely antibacterial (91.2%) with Piperacillin +Tazobactam (24 times) and Cefuroxime (15 times) being the most commonly prescribed antimicrobials on treatmentand discharge, respectively. Upon assessing the antimicrobial therapy, it was identified that antimicrobials werepredominantly prescribed empirically (57.4%) and monotherapy was observed more, both on treatment (52.8%) anddischarge (47.2%). A total of 79 different potential antimicrobial drug-drug interactions were identified, out of which,64.6% were major interactions. Ciprofloxacin + Metronidazole drug-drug interaction was the most common druginteraction observed 6 times, whereas clarithromycin and ciprofloxacin caused the greatest number of interactions witha frequency of 10 instances each. Ondansetron was the non-antimicrobial drug that caused the greatest number of druginteractions (21.2%). The present study reinforces that antibiotics and other antimicrobials are a group of verycommonly prescribed medications in the hospital with a variety of indications. An important, but often unheeded aspectof therapy is antimicrobial interactions with other drugs, which this study has highlighted.