STUDY OF ANTIBIOTIC SENSITIVITY PATTERN IN CHILDREN WITH NEPHROTIC SYNDROME PRESENTING WITH UTI

BACKGROUND:Nephrotic syndrome (NS) results in proteinuria of more than 3.5 g protein per day and is characterizedby edema,hyperlipidemia,hypoproteinemia and other metabolic disorders.Prevalence of UTI in nephrotic syndrome ishigh.It precipitates relapse and delays remission.AIMS AND OBJECTIVES:The aim of this retrospective study is to analyze the incidence of UTI,its Predisposing factorsalong with its bacterial and fungal etiologies in patients with NS and antibiotic sensitivity pattern in nephrotic childrenwith UTI.METHODS: This retrospective study was carried out in a tertiary care, CIVIL HOSPITAL,AHMEDABAD between July2018 and July 2019 among the admitted cases of nephrotic children under 12 years of age.Examinations for microscopy and cultures of urine, sputum, throat swab, blood and fluid were also carried out in thechildren,along with routine examination,if found necessary.Urinary specimens were collected by clean catch method following careful preparation of urethral orifices. Thespecimens were immediately inoculated on culture media. Identification of organisms and antibiotic sensitivity1susceptibility testing was performed according to CLSI guidelines 2010 by Kirby –Bauer disc diffusion method.RESULTS: Total 41 nephrotic children were enrolled.Incidence of UTI was fairly high in nephrotic syndrome,especiallyin frequent relapse (48.48%). Kleibsella pneumonia (45.5%) was the most common organism, followed by E.coli(24.24%),responsible for UTI in both first episode and frequent relapse of nephrotic syndrome in the following study.CONCLUSION: As per the study, common isolates of UTI in nephrotic syndrome have developed resistance tocommonly used oral or parenteral drugs.In my study,it is observed that colistin was the most sensitive parenteral drugfor all isolates followed by Meropenem and aminoglycoside.