Open AccessA STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS
Author(s) -
Shajahan Shajahan,
Koneru Sri Lahari,
P. Kiranmai
Publication year - 2021
Publication title -
paripex indian journal of research
Language(s) - English
DOI - 10.36106/paripex/0302859
Subject(s) - creatinine , uric acid , medicine , hyperuricemia , diabetes mellitus , blood sugar , endocrinology , type 2 diabetes mellitus , renal function , gastroenterology
BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and isassociated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemiaand Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerularpressure leading to renal complications.High serum creatinine is an indicator of renal compromise.OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to findassociation between them.METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 DiabetesMellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, FastingBlood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulterAU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBSand creatinine was analysed statistically.RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value <0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value<0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugarlevels when compared to subgroup with serum uric acid <7 mg/dl.CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared tocontrols.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,itis important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.