Open AccessDIAGNOSTIC ACCURACY OF XPERTMTB/RIF ASSAY IN DETECTION OF PULMONARY TUBERCULOSIS AND RIFAMPICIN RESISTANCE IN COMPARISON WITH CONVENTIONAL METHODS..
Author(s) -
BV Ramana,
A. Srikar,
Prashant Prakash,
Abhijit Chaudhury
Publication year - 2019
Publication title -
international journal of scientific research
Language(s) - English
DOI - 10.36106/ijsr/7501553
Subject(s) - genexpert mtb/rif , sputum , medicine , rifampicin , tuberculosis , pulmonary tuberculosis , mycobacterium tuberculosis , microbiology and biotechnology , pathology , biology
Tuberculosis is one of the oldest diseases with high morbidity and mortality. India accounts for one- fourth of the global TB burden(2.7million cases).Material and methods: A total 1056 patients were included in this study. All patients were requested to give two sputum samples, spot sputumsample (at the time of visit) and early morning sputum for mycobacterial testing. All spot samples tested with smear microscopy and XpertMTB/Rif assay. Rifampicin resistant samples compared with conventional method.Results: Out of 1056 sputum samples GeneXpert MTB Rif assay detected positive 204 (19.3%), not detected 827 (78.31%). There is significantdifference founded for positivity in spot samples and early morning sputum samples (P =0.0026). Rifampicins resistant were 8 (3.9%) andshown100% sensitivity, specificity with Conventional method.Conclusion: For diagnosing tuberculosis and detecting Rifampicin resistance GeneXpert MTB/RIF has been especially recommended.