Open AccessCOVID 19: AN OVERVIEW OF PATHOGENESIS, CYTOKINE STORM AND INTERFERONS AS A POTENTIAL DRUG THERAPY
Author(s) -
R. Ishwarya,
Amit Kumar,
K.V. Leela
Publication year - 2020
Publication title -
international journal of scientific research
Language(s) - English
DOI - 10.36106/ijsr/3514732
Subject(s) - cytokine storm , ards , immunology , medicine , immune system , cytokine , coronavirus , pathogenesis , pandemic , drug , inflammation , tumor necrosis factor alpha , disease , covid-19 , infectious disease (medical specialty) , lung , pharmacology
Novel Coronavirus (SARS-CoV-2) causing Coronavirus disease (COVID-19) has become a pandemic and has not been previously identified in humans. Transmission among humans occurs through respiratory droplets of infected individual. Patients infected with SARS-CoV-2 undergo acute respiratory distress because of Cytokine storm which serve as the major cause of morbidity and mortality in affected individuals. Cytokines are defined as non-structural proteins which are small with low molecular weight and have a greater regulatory influence in inflammation and immunity. They are considered as the intercellular messenger in the immune system.Therefore, this article provides a glimpse of advancements made in the area of SARS-CoV-2 infection where Cytokines may be a useful biomarker for both diagnostic and prognostic purpose and also as a therapeutic agent in targeting certain cytokines responsible for Acute Respiratory Distress Syndrome (ARDS) in SARS-CoV-2 infected patients.