Open AccessROLE OF VARIOUS IHC MARKERS IN CLASSIFICATION OF LUNG CARCINOMA ON ENDOBRONCHIAL BIOPSIES.
Author(s) -
Raj K. Gupta,
Namita Bhutani,
Sachet Dawar
Publication year - 2020
Publication title -
international journal of scientific research
Language(s) - English
DOI - 10.36106/ijsr/2633810
Subject(s) - subtyping , medicine , lung cancer , adenocarcinoma , immunohistochemistry , pathology , biopsy , carcinoma , basal cell , cancer , lung , oncology , gastroenterology , computer science , programming language
BACKGROUND: Lung cancer is the most frequently diagnosed cancer and leading cause among cancer mortality worldwide. An accurate classification is difficult in small biopsy specimens due to a variety of reasons. Therefore, there is an increasing need for additional diagnostic techniques such as immunohistochemistry. METHODS: This study was conducted on Endobronchial biopsies of One hundred and sixty patients were subjected to routine H & E and IHC staining. RESULTS: The patients were in age group of 25-75 years with a mean of 55.67 years with M: F ratio of 6.61:1. NSCLC constituted the major type, contributing to 83.1% of cases. Amongst, TTF-1 and napsin-A, the later had higher sensitivity (96.15%) as compared to TTF-1 (92.30%) for diagnosing adenocarcinoma. CONCLUSION: CK and p63 served as highly sensitive markers for diagnosis of squamous cell carcinoma and TTF-1 and napsin A for adenocarcinoma, forming an important diagnostic algorithm for subtyping of poorly differentiated NSCLC on small biopsies.