Open AccessROLE OF METFORMIN IN COVID-19
Author(s) -
K.Roshan praburaj,
Thangavelu Aruna
Publication year - 2020
Publication title -
international journal of scientific research
Language(s) - English
DOI - 10.36106/ijsr/2000342
Subject(s) - metformin , medicine , ampk , inflammation , ferritin , adverse effect , placebo , cytokine storm , covid-19 , disease , phosphorylation , biology , infectious disease (medical specialty) , pathology , insulin , biochemistry , protein kinase a , alternative medicine
Cytokine storm an uncontrolled over-production of soluble markers of inflammation which is systemic inflammatory response, is a major responsible for the occurrence of ARDS. Animal studies that have implicated ACE2 in the acute lung injury caused due to SARSCoV. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway. Metformin works through AMPK activation, which leads to phosphorylation of ACE2 and there is an structural change which unables SARS CoV2 to bind with it also it is known that metformin can reduce CRP level.This study aim to find the role of metformin in COVID 19 on disease regression by both clinical assessment and laboratory values.Single blinded randomised controlled trial, parallel group, placebo controlled study for 1 month duration at tertiary health care centre. There is significant clinical improvement in 69% of the subjects at day 6 and 31% at day 7 in metformin group. Also there is effective reduction in CRP level whereas Sr.Ferritin levels are moderately reduced. There is no adverse effect during study period.