ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH INTRAVENOUS DEXMEDETOMIDINE IN PAEDIATRIC AGE GROUP

Laryngoscopic manipulation and endotracheal intubation are noxious stimulus capable of producing tachycardia, arrhythmia, bronchospasm, larygospasm and hypertension.Dexmedetomidine is an Alpha 2 agonist with documented stress attenuation property. Dexmedetomidine has been seldom studied in Paediatric age This study was conducted in a view to find out the optimal dose of Dexmedetomidine for stress attenuation. To attenuate the hemodynamic response to laryngoscopy and endotracheal intubation with 3 different doses of intravenous Dexmedetomidine in Paediatric age group and to find out the optimal dose required for it. Paediatric patientswith sample size 90 undergoing Enucleation & Curettage for Adenotonsillitis, were enrolled for the study. Patients were divided into 3 groups (30 each) receiving: Group A 0.5mcg/kg of Dexmedetomidine. Group B 0.75mcg/kg of Dexmedetomidine. Group C 1mcg/kg of Dexmedetomidine. It was given as 20ml infusion over 10mins.The hemodynamic response was better obtunded in Group B and Group C, when compared with Group A.There was no clinically significant difference between Group B and Group C in any of the parameters at any point of time. So the dose of 0.75mcg/kg of dexmedetomidine is adequate to produce desired stress attenuation with minimal side effects compared to 1mcg/kg. Dexmedetomidine in a dose of 0.75mcg/kg is the optimal dose to attenuate stress response to larygngoscopy and endotracheal intubation with minimal adverse effects.