Open AccessInsulin resistance in PLHIV on HAART and HAART naïve PLHIV: A Cross-sectional Study
Author(s) -
P.K. Ganguly,
Ν. R. Das
Publication year - 2020
Publication title -
indian journal of applied research
Language(s) - English
DOI - 10.36106/ijar/3506686
Subject(s) - insulin resistance , dyslipidemia , medicine , metabolic syndrome , insulin , cross sectional study , antiretroviral therapy , cohort , viral load , lipodystrophy , human immunodeficiency virus (hiv) , immunology , disease , obesity , pathology
HAART (Highly active antiretroviral therapy) has transformed a fatal disease to a chronic, manageable disease. But long term toxicities are emerging after prolonged exposure to antiretroviral therapy(ART). Adverse metabolic effects like dyslipidemia, increased blood pressure, and insulin resistance(IR) have been attributed to HAART. Therefore, the use of HAART raises concerns regarding metabolic disorders and cardiovascular risk in HIV(Human immunodeficiency virus) infected patients. Objective: To determine the prevalence of insulin resistance in a cohort of HIV infectedpatients on HAART as compared to HAART naïve PLHIV(People living with HIV)Methods: A cross sectional study includes 53 subjects, out of which 26 werePLHIV on ART –Group I, 27 were ART naïve PLHIV-Group II was conducted. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) mathematical model. Statistical analysis was performed to assess the association between demographic, clinical characteristics, laboratory results and insulin resistance.Results: 69.5 % PLHIV on HAART showed IR, as compared to 37 % of ART naïvePLHIV (p= 0.01). MetS(Metabolic Syndrome) was found in 53.8% among PLHIV on ART , compared to 11.1% among ART naïve PLHIV(p= 0.001) .In the multivariate analysis, presence of metabolic syndrome was found to be directly associated with insulin resistance.