z-logo
open-access-imgOpen Access
LEUKOCYTE ADHESION DEFECT: A CASE SERIES OF 3 CHILDREN
Author(s) -
Neha Rehalia,
Vivek Chaudhary,
Avinash Sharma
Publication year - 2020
Publication title -
global journal for research analysis
Language(s) - English
DOI - 10.36106/gjra/8614228
Subject(s) - leukocyte adhesion deficiency , cd18 , adhesion , medicine , integrin , primary immunodeficiency , cell adhesion molecule , immunology , pathology , chemistry , disease , receptor , organic chemistry
Leukocyte adhesion defect (LAD) is a rare, autosomal recessive primary immunodeficiency disorder of phagocytes, in which there is defective aggregation at the site of infection due to the absence of surface integrins. Diagnosis is based primarily on flowcytometric analysis of neutrophils for the surface expression of CD11, CD18 and CD15s. We describe here a case series of 3 children presented to us within a period of one year and diagnosed as LAD. Diagnosis was made on the basis of clinical features and simple laboratory investigations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here