COMPARISION OF VARIOUS DOSES OF INTRAVENOUSLY ADMINISTERED DEXMEDETOMIDINE WITH FENTANYL ON HAEMODYNAMICS TO INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANESTHESIA

Background: During general anesthesia , direct laryngoscopy and intubation results in a profoundsympathoadrenal response which leads to tachycardia , hypertension and in predisposed individualsmay lead to myocardial ischemia and arrhythmias. Various drugs such as opioids, lignocaine, propofol, beta blockers, alphaagonists have been used to minimize these adverse responses. Methods: 90 patients ASA1, ASA2 scheduled to undergoelective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlledtrial. ey were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10minutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10minutes prior to induction. Results: Both study groups(B & C) were comparable with respect to there heart rate at base line, 1minute,2.5 minutes, 5 and 10 minutes after administration of the study drug. Group C(Dexmedetomidine 1 g) demonstrated agreater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) werecomparable to their SBP at base line 5 and 10minutes Group C demonstrated a better suppression of the pressor response tointubation compared to other two groups