Open AccessSPECTROPHOTOMETRIC ANALYSIS OF TABLETS OF PIROXICAM USING MELTED NIACINAMIDE AS SOLVENT
Author(s) -
R. K. Maheshwari,
Ayushi Mohadikar,
Pawan Mulani
Publication year - 2019
Publication title -
global journal for research analysis
Language(s) - English
DOI - 10.36106/gjra/3208112
Subject(s) - niacinamide , piroxicam , reagent , solubility , chromatography , solvent , chemistry , nicotinamide , organic chemistry , medicine , alternative medicine , pathology , enzyme
In the present research work, a novel method for spectrophotometric estimation of piroxicam tabletsusing melted niacinamide as solvent was developed. The main objective of the research is to show thatsolids also possess solubilizing power. The current study deals with a novel spectrophotometric analytical technique forquantitative estimation of piroxicam in tablets using melted niacinamide as solvent. According to the theory proposed byMaheshwari, each & every substance possesses solubilising power; the substance may be a gas, solid or liquid. Niacinamideimbibes large solubilizing power to piroxicam and having approximate solubility 110 mg per gm of melted niacinamide (135°C)whereas aqueous solubility of piroxicam is 0.40 mg/ml at room temperature. Niacinamide does not interfere above 300 nm inthe spectrophotometric analysis. Calibration curve of piroxicam was plotted by recording the absorbances of standardsolutions of the drug (5, 10, 15, 20 and 25 µg). The absorbances were observed at 358 nm against respective reagent blanks. Thepercent label claims were found very close to 100.0 (99.08 ±1.764 and 100.93 ±1.303) indicating the accuracy of the proposedmethod. Percent recoveries estimated by the proposed method are close to 100.0 (99.92 ±1.605 to 101.74 ±1.663) with signicantlow values of percentage deviation and standard error. Thus, it may be concluded that the proposed method is simple, safe, andprecise, and excludes the use of toxic organic solvents.