Open AccessASSOCIATION OF DIABETES IN PREGNANCY WITH THYROID DYSFUNCTION AND AUTOIMMUNITY
Author(s) -
Ekta Kanojia,
Suman Lata Mendiratta,
Vineeta Sarbhai
Publication year - 2021
Publication title -
global journal for research analysis
Language(s) - English
DOI - 10.36106/gjra/3111101
Subject(s) - medicine , pregnancy , gestational diabetes , diabetes mellitus , subclinical infection , thyroid peroxidase , obstetrics , type 1 diabetes , thyroid , endocrinology , gestation , genetics , biology
PURPOSE This study was undertaken to find out the proportion of women with diabetes in pregnancy complicated by thyroid dysfunction compared to non-diabetic pregnant women. To find out the association, if any, of thyroid dysfunction and anti-thyroid peroxidase (anti-TPO) antibodies during pregnancy with type1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus (GDM) and non-diabetic pregnant women.METHODS A cross-sectional observational study was conducted in a tertiary care teaching hospital in New Delhi, India, for a period of one year. 100 women with diabetes in pregnancy and 100 non-diabetic pregnant women were recruited from the ante-natal clinic. The women were evaluated for thyroid dysfunction, thyroid autoimmunity and were managed according to the hospital’s protocols. The relevant data were recorded and statistical analysis was done.RESULTS 24% of women with diabetes in pregnancy and 8% of non-diabetic women had hypothyroidism. Subclinical hypothyroidism was most prevalent in women with GDM (15.25%) and overt hypothyroidism was most prevalent in women with type 1 DM (28.57%). Mean serum TSH levels were highest in women with type 1 DM. Positive anti-TPO antibodies were significantly associated with diabetes in pregnancy compared to non-diabetic women (p=0.02). Amongst women with diabetes in pregnancy, positive anti-TPO antibodies were significantly associated with type 1 DM (p<0.01)CONCLUSIONS Thyroid disorders are commonly associated with diabetes in pregnancy. The study findings suggest routine screening for thyroid abnormalities in diabetic pregnant women.