Open AccessCLINICAL EVALUATION AND MANAGEMENT OF SOLITARY NODULE OF THYROID IN EUTHYROID PATIENTS
Author(s) -
M. Venkateswarulu,
Anik Datta,
Rajitha Rajitha,
Renuka Renuka,
Anand Anand,
Ravindra Ravindra,
Deepak Deepak
Publication year - 2019
Publication title -
global journal for research analysis
Language(s) - English
DOI - 10.36106/gjra/1409615
Subject(s) - medicine , euthyroid , nodule (geology) , thyroid , thyroid nodules , population , solitary pulmonary nodule , malignancy , thyroid carcinoma , radiology , pediatrics , computed tomography , paleontology , environmental health , biology
BACKGROUND: Solitary nodules of the thyroid have been the area of focus in research since WarrenColein 1949. It is an area of research with much potential because of its diverse clinicalpresentation andits wide-ranging etiology and often the risk of malignancy. But the studiesassessing the prevalence and clinical prole ofsolitary thyroid nodules are relatively scarcefrom India. Hence the current study was conducted with the objective ofdetermining theprevalence of solitary nodule of thyroid in general Population and to determine the proportion of a solitarynodule of thyroid turning out to be multinodular goitre on subsequentevaluation. The study has also assessed the role of FNACin the management of solitarynodule of the thyroid and estimatedincidence of carcinoma as a cause of solitary Noduleof thethyroid to determine the underlying cause of Solitary nodule of thyroid (SNT) by theHPE.MATERIALS & METHODS:This study was a prospective study conducted in the Department of General surgery inKATURIMEDICAL COLLEGE fromNovember 2016 to May 2018 for a period of 1.5years.The study population included Solitary Noduleof Thyroid admitted to theDepartment of General surgery at Katuri medical collegewere considered as thestudy population.The prevalence was computed against all the OPD attendees in thedened study period. The ndings of ultrasonography,FNAC and HPE were comparedusing cross tabulation. Since the study did not attempt to test any hypothesis, No statisticaltestof signicance was used. IBM SPSS statistical software version 21 was used for data/analysis.RESULTS: During the study period, the total number of subjects attending the Outpatient departmentwere 6485.Among all theoutpatient attendees, the prevalence of solitary thyroid nodulewas 1.23% with 95% CI ranging from 0.96% to 1.5%.Out of 80clinically diagnosed solitarythyroid nodule cases multi nodular goitrewas found in 7 (8.8%) subjects on subsequentevaluation.In USG, 51.3% had Hyper Echogenic Nodule while 23.8% had MixedEchogenic Nodule. In 8.8%, the nodule turned out to be apart of Multi Nodular Goiter while7.5% had Suspicious Multi Nodular Goiter. In FNAC, 86.2% of the nodules were benignonFNAC. The majority (32.50%) were Benign Colloid Nodules. 26% were colloid nodules inFNAC. 13.8% of the nodules weremalignant in FNAC. Papillary thyroid carcinoma wasseen in 12.5% in FNCAC. In HPE, the majority (78.5%) were benignnodules. Only 21.5%were malignant. In HPE, 32.5% were a benign follicular adenoma. The proportion of Colloid Nodule was31.3%, and nodular goitre was 5%. The proportion of Papillary Thyroid Carcinoma, Hashimoto's thyroiditis, Well-DifferentiatedPTC, Anaplastic ca. of Thyroid was 13.80%, 3.80%, 2.50% and 1.3% respectively.CONCLUSIONS: The current study had assessed the burden and clinic pathologicprole of solitary thyroidnodulecases. The study ndings is an important addition to the existing evidence and guide the clinicians at various levels inevidence based evaluation and management of the patients with solitary thyroid nodule.