Open AccessEVALUATION OF SERUM CREATININE LEVEL IN SUBCLINICAL HYPOTHYROIDISM
Author(s) -
Deepa Thadani,
Manna Lal Kumawat,
Sarla Mahawar,
Ajay Jain
Publication year - 2021
Publication title -
global journal for research analysis
Language(s) - English
DOI - 10.36106/gjra/0706438
Subject(s) - subclinical infection , creatinine , euthyroid , medicine , endocrinology , triiodothyronine , population , thyroid , renal function , hormone , thyroid function , creatine , thyroid stimulating hormone , physiology , environmental health
Background: Hypothyroidism is a common endocrinal disorder caused by insufcient production ofthyroid hormones. Subclinical hypothyroidism (SCH) can be dened as a state of high serum thyroidstimulating hormone (TSH) levels (less than 10µIU/ml) with normal serum free thyroxine (fT ) and triiodothyronine (fT ) levels in 4 3the presence or absence of symptoms. Creatinine is a chemical waste product that is produced by muscle metabolism.Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Thyroid dysfunctioncan affect renal physiology and development, and on the other hand, kidney disorders can inuence thyroid function. Thisstudy was aimed to nd out the status of serum fT , fT ,TSH and serum creatinine levels in subclinical hypothyroid cases and 3 4healthy controls. Materials and Methods: The present study is descriptive case control study, was conducted in the Departmentof Biochemistry, J.L.N. Medical College and Associated group of Hospitals, Ajmer (Raj.). 130 cases of subclinicalhypothyroidism attending Medical OPD of J.L.N. Hospitals were included and 50 age-sex matched euthyroid controls wereselected. Results: The mean serum creatinine levels were found to be signicantly high in subclinical hypothyroid cases(0.99+ 0.19 mg%) as compared to healthy controls (0.75 + 0.15 mg%), (p<0.0001). Conclusion: Serum creatinine can be used as abiomarker for early detection of subclinical hypothyroidism in general population to prevent the morbidity and mortality whichare associated with hypothyroidism. Early diagnosis and intervention of subclinical hypothyroid and their cluster of risk factorcan prevent the renal dysfunction.