Open AccessFeasibility of Ultrasound-Guided Peritoneal Perfusion with Ozone in the Treatment of Chronic Pelvic Pain: A Bicenter Retrospective Analysis
Author(s) -
Manyu Zhang,
Tong Li,
Xiaoyan Qian,
Hui Liu,
Qian-Nan Zhao,
Cai-Cai Liu,
Yong Wang,
John P. Williams,
Jian-Xiong An
Publication year - 2021
Publication title -
pain physician
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 99
eISSN - 2150-1149
pISSN - 1533-3159
DOI - 10.36076/ppj.2021/24/e367
Subject(s) - medicine , ozone therapy , visual analogue scale , anesthesia , retrospective cohort study , surgery , alternative medicine , pathology
Background: Numerous therapies have been developed for the treatment of chronicpelvic pain (CPP). Oxygen-ozone therapy is a new method for the treatment of CPP.Objectives: This article evaluated the feasibility of ultrasound-guided peritoneal perfusionwith ozone in patients with CPP.Study Design: This is a bicenter retrospective study.Setting: The study was conducted at 2 pain centers of a university hospital.Methods: The medical records of patients with CPP (n = 60) from March 2016 untilOctober 2018 were collected and reviewed. Group A contained 19 patients who weretreated with a 1500 mcg dose of ozonated water (10 mcg/mL concentration and 150 mLvolume), group B contained 23 patients using the same dose of ozonated water but a 15mcg/mL concentration and 100 mL volume. Group C included 18 patients using a similarozone dose but delivered in an oxygen-ozone mixture (15 mcg/mL concentration and 100mL volume oxygen-ozone mixture). Visual Analog Scale (VAS) scores for pain of the 3 groupswere compared at pretreatment, posttreatment, 1, 3, and 6 months posttreatment. Theinjection pain was evaluated using a 4-point verbal rating scale. Quality of life (QoL), anxiety,and depression were assessed at pretreatment and at 6 months posttreatment.Results: The VAS scores of the 3 groups decreased over time following treatment. GroupA showed much higher pain scores compared with groups B and C at 1, 3, and 6 monthsposttreatment. However, the injection pain for groups B and C was higher than group A, butthere was no difference seen between group B and C. At 6 months posttreatment, the QoLfor all patients improved compared with pretreatment, whereas the anxiety and depressiondid not demonstrate differences.Limitations: The main limitations of this study are the retrospective study design, limitedcase number, and short follow-up period.Conclusions: Ultrasound-guided peritoneal perfusion with ozone is a feasible therapy forpatients with CPP.Key words: Chronic pelvic pain, ozone, peritoneal perfusion