Open AccessIdentification of Candidate Genes Associated with Postherpetic Neuralgia Susceptibility
Author(s) -
Min Yan
Publication year - 2020
Publication title -
pain physician
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 99
eISSN - 2150-1149
pISSN - 1533-3159
DOI - 10.36076/ppj.2020/23/e281
Subject(s) - postherpetic neuralgia , medicine , odds ratio , genetic predisposition , genotype , confidence interval , pharmacogenetics , population , allele , neuropathic pain , genetics , anesthesia , gene , biology , disease , environmental health
Background: Postherpetic neuralgia (PHN) is one of the most common complications of herpeszoster (HZ). Heritable factors have been found to play a role in various clinical pain symptoms.However, the effect of gene variability on the susceptibility of PHN remains poorly understood.Objectives: The aim of this study was to evaluate whether genetic variation in pain pathwaygenes was associated with PHN susceptibility in the Chinese population.Study Design: Case–control study.Setting: Department of Anesthesiology and Pain Medicine in a university hospital.Methods: Seventy patients with PHN and 111 patients with HZ without developing PHN wereenrolled. All patients received standardized antiviral agents and analgesics as needed during theacute phase of HZ. Twenty-four candidate genetic polymorphisms in 12 genes (IL1B, SCN9A,KCNK9, TRPV1, P2RX7, HTR1A, HTR2A, ADRB1, ADRB2, BDNF, COMT, and OPRM1) weregenotyped in all patients. Multivariable logistic regression analyses were used to identify geneticvariations associated with PHN susceptibility while controlling for potential confounders.Results: Our results suggested that only variation in P2RX7 gene was associated with PHNsusceptibility. The P2RX7 rs7958311 AG heterozygous genotype carriers had a decreased risk forPHN in the overdominant model (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.21–0.77; P= 0.005), and codominant model (OR, 0.44; 95% CI, 0.20–0.98; P = 0.045). The P2RX7 rs7958311GG homozygote genotype was associated with an increased risk for PHN under a recessive model(OR, 2.15; 95% CI, 1.01–4.56; P = 0.046). There were no significant associations between theother 23 single-nucleotide polymorphisms and PHN susceptibility.Limitations: Lack of validation cohort to verify the findings.Conclusions: In the present study in the Chinese population, we found purinergic receptor P2X7rs7958311 may contribute to PHN development after HZ. Future larger independent cohorts arewarranted to replicate these initial findings.Key words: Herpes zoster, postherpetic neuralgia, polymorphisms