Open AccessThe Association of rs4753426 Polymorphism in the Melatonin Receptor 1B (MTNR1B) Gene and Susceptibility to Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-analysis
Author(s) -
Peng Yang,
Hao Líu,
Lin Jian,
Huilin Yang
Publication year - 2015
Publication title -
pain physician
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 99
eISSN - 2150-1149
pISSN - 1533-3159
DOI - 10.36076/ppj.2015/18/419
Subject(s) - medicine , meta analysis , odds ratio , scoliosis , medline , confidence interval , melatonin receptor , single nucleotide polymorphism , bioinformatics , genotype , surgery , melatonin , genetics , gene , biology , biochemistry
Background: Adolescent idiopathic scoliosis (AIS) is a tridimensional structural deformity ofthe spine that may deteriorate progressively, leading to significant functional limitations and painproblems. Several previous studies have implicated the rs4753426 single nucleotide polymorphismin the melatonin receptor 1B (MTNR1B) gene in the etiology of AIS. However the sample sizes werelimited and the findings of those studies were inconsistent. An overall assessment of the evidencesupporting this association has not been previously conducted.Objectives: To provide a comprehensive assessment and synthesis of the currently availableevidence on the association between rs4753426 and AIS.Study Design: A systematic review and meta-analysis.Setting: University hospital, China.Methods: This review followed the Preferred Reporting Items for Systematic Review and MetaAnalyses guidelines. PubMed (MEDLINE), EMBASE, Scopus databases, and WANFANG databaseswere systematically searched through December 2014 to identify relevant studies following asensitive strategy. Statistical analysis was performed using the Review Manager 5.2 software.Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimatedusing the fixed-effect inverse variance model for allelic (C vs. T) and genotypic comparisons.Results: Four papers including 5 studies which involved 2,552 AIS cases and 2,738 controlswere identified for this meta-analysis. The results showed that C allele of the rs4753426 wassignificantly associated with AIS (OR = 1.12, 95% CI: 1.03 – 1.21, P = 0.01). CT and CC genotypeswere 26% (OR = 1.26, 95% CI: 1.04 – 1.53, P = 0.01) and 28% (OR = 1.28, 95% CI: 1.05 – 1.56,P = 0.01), respectively, more likely to have AIS compared with CC genotype. As for the dominantmodel (CC+TT vs. TT), summary ORs showed statistically significant association with AIS (OR =1.28, 95% CI: 1.06 – 1.53, P = 0.009). Compared with the CT+TT genotype, the summary ORsof the CC genotype showed marginally statistically significant association with AIS (OR = 1.11, 95% CI: 0.99 – 1.24, P = 0.07). The subgroup meta-analysis results showed the C allele and eachgenotype were significantly associated with AIS in the Asian group but not in the Caucasian group.Limitations: Paucity of available literature.Conclusions: To our knowledge, there has been no meta-analysis to analyze the associationbetween rs4753426 polymorphism in the MTNR1B gene and AIS. This systematic review wasa comprehensive analysis of the currently available evidence, and found an overall significantassociation of rs4753426 polymorphism with the risk of AIS, especially in the Asian population.Further investigation of this association is necessary in other populations.Key words: Adolescent idiopathic scoliosis, MTNR1B, Rs4753426, single nucleotidepolymorphism, occurrence, curve severity, meta-analysis