Open AccessSize Controlled Synthesis of PHB Microparticles
Publication year - 2019
Publication title -
international journal of recent technology and engineering
Language(s) - English
Resource type - Journals
ISSN - 2277-3878
DOI - 10.35940/ijrte.d1147.1284s219
Subject(s) - polyhydroxybutyrate , particle size , response surface methodology , materials science , microparticle , adsorption , drug delivery , nanotechnology , polymer , chromatography , chemical engineering , biomedical engineering , chemistry , composite material , organic chemistry , medicine , engineering , bacteria , genetics , biology
Polymer microparticles are being widely considered for delivery of drugs during therapies, by stabilizing and ensuring biological activity, which facilitates adsorption and delivery of these drugs to the target site. In the present study, size formulation of PHB (polyhydroxybutyrate) microparticles was performed using a 3-factor 2-level Response Surface Methodology (RSM) design. The results were analyzed by DLS measurements. Experimental responses of a total of 20 formulations resulted in various particle sizes ranging between 100nm to ~8000 µm. These size controlled microparticles can be utilized for various therapeutic applications.