Open AccessOne-Pot Synthesis of N-Benzyl Substituted 2- Aminothiophene-3-Carboxilic Acid Scaffold and their Antibacterial Activity
Author(s) -
Venugpalarao vikram,
Karteek Rao Amperayani,
Umadevi Parimi
Publication year - 2019
Publication title -
international journal of innovative technology and exploring engineering
Language(s) - English
Resource type - Journals
ISSN - 2278-3075
DOI - 10.35940/ijitee.k1567.1081219
Subject(s) - pharmacophore , antibacterial activity , chemistry , antimicrobial , bacteria , combinatorial chemistry , scaffold , carboxylic acid , carbon 13 nmr , organic chemistry , stereochemistry , biology , medicine , genetics , biomedical engineering
2-aminothiophene is an important pharmacophore in medicinal chemistry which exhibits a wide spectrum of biological activities. An efficient one pot synthesis has been established for the synthesis of novel series of N-benzyl substituted 2-aminothiophene-3-carboxylic acid derivatives. The synthesized compounds were characterized by nuclear magnetic resonance (1H and 13C NMR) and Mass spectrometry. The antimicrobial activity of these compounds were tested on Gramnegative bacteria and Gram-positive bacteria. Among all the synthesized compound 2b, 2c, 2f were found to have good antibacterial activity. Conjugation of the compound and carboxylic acid group has enhanced the activity of all the compounds