Open AccessInnovative Technology for Modeling Cancer Grow Regulatory Mechanisms with Taking into Account Micro-RNA Action
Author(s) -
Mahruy Saidalieva,
Mohiniso Hidirova
Publication year - 2019
Publication title -
international journal of innovative technology and exploring engineering
Language(s) - English
Resource type - Journals
ISSN - 2278-3075
DOI - 10.35940/ijitee.a5174.119119
Subject(s) - action (physics) , coding (social sciences) , rna , computational biology , computer science , metastasis , biological system , cancer , biology , neuroscience , gene , mathematics , physics , genetics , statistics , quantum mechanics
This article is devoted to modeling regulatory mechanisms of human molecular-genetic systems activity during cancer origin and development with taking into account non-coding circulating regulators. The paper draws on results made by using methods of quantitative and qualitative analysis of functional-differential equations. Computational experiments have shown that for certain values of internal and external states there are the following regimes: programmed cell death (apoptosis), stationary state, self-oscillations, irregular behavior (cancerous growths) and a sharp destructive change - the “black hole” effect (metastasis) in depending on various concentrations of micro-RNA. The paper provides a new mathematical and computer models able to describe regulatory mechanisms of cancer taking into account spatial and temporal relations.