Open AccessSynthesis of Novel and Bio-vital Pyridine based Ternary Compounds: Multi-Spectral Characterization, Biological Examination, Molecular Docking and In-Silico ADMET Profile
Author(s) -
S. Syed Ali Fathima,
E.R. Nagarajan
Publication year - 2019
Publication title -
international journal of engineering and advanced technology
Language(s) - English
Resource type - Journals
ISSN - 2249-8958
DOI - 10.35940/ijeat.a1154.1291s419
Subject(s) - combinatorial chemistry , in silico , chemistry , docking (animal) , nucleic acid , ternary operation , dna , ligand (biochemistry) , stereochemistry , biochemistry , receptor , medicine , nursing , computer science , gene , programming language
The novel bio-crucial ternary compounds were synthesized and characterized by several spectral techniques and other physicochemical analysis. From all the measurements, octahedral structure was proposed for all the synthesized compounds. Moreover, the synthesized compounds have driven for their biological outlook. The DNA synergy was achieved by UV-studies displayed that the prepared complexes may interact with nucleic acid through intercalated pathway. In addition, the antimicrobial analysis of synthesized compounds explicated the compounds were best antibiotics against selected microbes. The gel electrolysis study showed that the major DNA bifurcation activity of the complexes to separate the pUC 18 nucleic acid fragment. The in-vitro antiproliferative activity of the complexes is investigated on breast and liver tumour cell panel confirmed that the metal complexes have considerable metastatic tumour ability. The antioxidising report evident that the metal complexes carry the attractive talent to chase the radical correlated to ligand. The drug-like evaluations exposed that the mixed ligand complexes possess substantial drug-like efficiency based on Lipinski's set of laws. Ultimately, the docking simulations are validated to realize the binding mode of the ternary compounds with FGFR protein and 1BNA.